The Sophia Huntington Parker Home for Pythian Sisters was a provision in the will of Mrs. Parker herself, made for any group to build and maintain a home for elderly woman. Many believed the home was a converted mansion but it was constructed in 1914, solely for the purpose of providing a home. The Pythian Sisters of Ohio supported the non-profitable organization, where when a Pythian sister took up residence in the home, she would deed all her possessions to it. At the time there was a maximum capacity of thirty women and there was a staff of twelve to assist the women with maintenance. Mrs. Leone Walters was a licensed practical nurse there, and there was a physician on call at all times for the safety of the women. The home went through some changes over later years. It was remodeled in 1965, with the goal being that the home would act more like a rehabilitation center than a home for elderly women, and both men and women on Medicare and Medicaid would be accepted. However the home is no longer run by Pythian sisters and the last resident left in August of 2000. In 2008 after the Pythian Sisters owned the home for 94 years, it was auctioned off to a developer from Akron. Many were saddened by the loss of the home, being that it has been around for such a long time, but Laura Auble, president of the Sophia Huntington Parker-Pythian Sisters Home's board of director’s states that "You can't hold onto things forever when you're not getting any use out of them."

The building was built in 1914 by members of the Pythian Sisters organization. The Pythian Sisters became interested in building the old ladies home as soon as they found out the land was available, because they thought that the building would only benefit the city, so a large group of members of the Pythian Sisters organization came down from Cleveland to build the house. The building was dedicated as one of Medina's noteworthy institutions in June 1916, and it was a building known for a great atmosphere that always made you feel at home. Up until the house was sold in 2008, it was Medina's most historical and most memorable home for the elderly.